JAMA 26 Jan 2011 Vol 305
391 Stroke medicine grew up in the 1990s: like heart failure medicine, it shone welcome light on a large and neglected group of patients with organ damage who had been written off as unsalvageable. This was a Very Good Thing in itself, but its proponents then went on to declare that good stroke care could only be provided in designated stroke units, and went on to run some not-very-randomised trials to prove it. They also began to talk up the evidence for the benefits of immediate thrombolysis, which are real but extremely modest. These fashions spread to the USA following recommendations of the Brain Attack Commission in 2000, and this study evaluates the effect in New York State in 2005-6, comparing mortality and the use of thrombolysis in 31,000 patients with stroke, equally divided between hospitals with or without stroke units. There was a large difference in thrombolysis use - 4.8% in stroke units, versus 1.7% elsewhere; but a very small difference in mortality at 30 days - 10.7% versus 12.5%. It would be nice if someone could go on to look at a wider range of patient-important outcomes too.
NEJM 27 Jan 2011 Vol 364
303 One of the nightmare jobs you are glad someone else does is finding veins in haemodialysis patients. Someone who does this from time to time will be very glad to read this study showing that recombinant tissue plasminogen activator is twice as good as heparin at keeping central venous lines open and three times as good at preventing bacteraemia. Luck will be needed to get hospital trust to meet the extra cost.
http://www.nejm.org/doi/full/10.1056/NEJMoa1011376
313 The New England Journal allows you free access to this paper on Ventricular Tachyarrhythmias after Cardiac Arrest in Public versus at Home and in case you are inclined to spurn this generous offer, take a look at these excerpts from the editorial about it by Gust H Bardy M.D.:
If CPR were a drug or a surgical procedure, its value would be tested prospectively, but it has not been. Could it be that innovation in the field is hampered by a reluctance to let go of an entrenched approach that has only the appearance of value?
Knowledge of the absolute measured value of CPR would have a profound influence on the direction of research on sudden cardiac arrest and the conservation of resources. More than 40 years after its inception, CPR has never been compared with no CPR in a randomized trial involving patients with sudden cardiac arrest. Although not performing CPR is a heretical idea, it is not unethical; clinical equipoise does exist for the comparison of chest compression with no compression.
Click the links and read on
http://www.nejm.org/doi/full/10.1056/NEJMoa1010663
http://www.nejm.org/doi/full/10.1056/NEJMe1012554
351 Chronic thromboembolic pulmonary hypertension sounds nasty and almost bound to be underdiagnosed, and indeed it is both. It is fairly easy to spot when it follows acute pulmonary embolism as it does in 2-4% of PEs. But we simply don't know how often it occurs without overt PE, because much of it may lie hidden as "idiopathic" pulmonary hypertension and not present until right heart failure has set in. By which time it is a bit late: the "heroic" treatment is surgical: "Pulmonary thromboendarterectomy is performed with the use of cardiopulmonary bypass with intermittent circulatory arrest to permit dissection from the main pulmonary arteries to the subsegmental branches." Not surprisingly, it doesn't always work, and many patients are too sick to have it done.
http://www.nejm.org/doi/full/10.1056/NEJMra0910203
Lancet 29 Jan 2011 Vol 377
393 Eltrombopag! Eltrombopag! O keep it in your doctor's bag! was sang when first encountered this orally available thrombopoeitin receptor agonist. It makes you make platelets and so reverses chronic immune thrombocytopenia - as long as you keep taking the tablets. The Lancet has decided to print the RAISE study as it first appeared on their website, despite some second thoughts by its authors - if you like this kind of thing, it's all explained in an editorial by Lancet house staff on p.360. Apparently they made some claims about the inferiority of eltrombopag's main competitor drug, romiplostim, which may not be sustainable. Plus failing to mention that their patients were splenectomised. Naughtiness.Eltrombopag! Eltrombopag! Doctor will keep it in his bag,Depending on what it might cost him -He might just plump for romiplostim.
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(10)60959-2/abstract
BMJ 29 Jan 2011 Vol 342
275 And of course I have to declare an interest in the Easily Missed series, which I helped to set up. I think I may even have suggested Joint Hypermobility Syndrome and I'm certainly glad that it produced such a good contribution, well illustrated and a bit longer than most. Please let's have your further submissions to keep this series going indefinitely - after all, there's no end to what you can miss in medicine. But don't be surprised if we keep your article short and down to ten references.
http://www.bmj.com/content/342/bmj.c7167.extract
Arch Intern Med 24 Jan 2011 Vol 171
134 A drug that produces a 41% reduction in recurrent cardiovascular events following myocardial infarction - now wouldn't that get some marketing! The only drug that comes near that is alcohol - which does get a lot of marketing, but not for that reason. Here there is no drug at all: just talking. Mind you, quite a lot of talking, in the form of 20 two-hour sessions of traditional cognitive behavioural therapy in the first year after MI. Now let's say this was a new antiplatelet drug produced by pharma, and sold at £115 per month (a generous estimate of the cost of the CBT): every post-infarct patient would be clamouring for it to be funded by the NHS. But it's only CBT, which is also the best treatment for lots of other things. So forget about ever being able to get it.
http://archinte.ama-assn.org/cgi/content/abstract/171/2/134
Showing posts with label cardiovascular. Show all posts
Showing posts with label cardiovascular. Show all posts
Tuesday, 1 February 2011
Tuesday, 2 March 2010
SNIPPETS FROM JOURNALS
The following are all from www.cebm.net
Lancet 27 Feb 2010 Vol 375
727 Not long ago, someone had a myocardial infarction on a transatlantic flight. So what does a professor of surgery do under these circumstances? Possibly take an aspirin and pray a good deal. He should have squeezed his arm repeatedly for periods of five minutes or so at a pressure above systolic. Believe it or not, this simple manoeuvre can reduce the area of myocardial damage, as proved in this Danish trial where patients with presumptive MI were randomised to have the squeezing done (or not done) by a sphygmomanometer in the ambulance conveying them to hospital. This is known as ischaemic preconditioning, though in such circumstances it should perhaps be known as simultaneous ischaemic conditioning. There were no hard end-points in this trial but a convincing reduction in damage on myocardial perfusion imaging at 30 days. More trials are needed, but meantime there seems no possible reason not to give it a try.
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(09)62001-8/abstract
752 This is a rather rambling 10-page review of dilated cardiomyopathy. The Panel of Mechanisms covers just about everything except interference by aliens, and there's a panel of gene loci too, but no panel of relative frequencies and prognoses for each aetiology. There is no mention of spontaneous recovery, which can't be rare if it has been seen twice.
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(09)62023-7/abstract
763 Say you had stable coronary artery disease: would you want an angiogram? And if the cardiologist saw a stenosis, would you want a stent put in? A year or two ago, these questions would have seemed like no-brainers, but then along came COURAGE and BARI-2D showing that medical treatment is as good as percutaneous intervention. Do you truly and deeply believe this, though? See how you feel when you read this review by two Swiss and an American cardiologist. It presents enough evidence to allow a tailored approach, and says that it "proposes a treatment algorithm that is applicable to daily clinical practice." The word "algorithm" is to be avoided, but people who use it generally refer to a flow chart, but there isn't one. http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(10)60168-7/abstract
BMJ 27 Feb 2010 Vol 340
459 A useful systematic review compares the results of carotid endarterectomy vs. carotid stenting in 11 randomised trials. On the face of it, endarterectomy wins, because the risk of periprocedural stroke is less; in the longer term there is little difference. Techniques and experience increase all the time - it may happen that the guy who puts in stents near you does that better than the guy who scrapes arteries. So more studies are justified and the matter is not quite settled yet.
http://www.bmj.com/cgi/content/full/340/feb12_1/c467
JAMA 17 Feb 2010 Vol 303
631 The Women's Genome Health Study is a prospective cohort of 19,313 women followed up for a median of 12.3 years, during which they experienced 777 cardiovascular events. In these women, 101 single nucleotide polymorphisms were added with one or two other genomic factors to create a genetic risk score. Surely this would usher in a new era of refined cardiovascular risk prediction? Well, actually it showed no significant association with the incidence of total cardiovascular disease: a simple family history alone was more predictive. On the other hand, there is so much anonymized data about the participants that you could probably find out the full disease status of any individual if you could identify their genome from some other source. This is discussed in a fascinating commentary on p.659. Genomic studies seem almost disconcertingly useless at the population level, but if you know 35,000 gene variants in a single individual, you can measure their left ventricular mass more accurately than if you had an echocardiogram.
http://jama.ama-assn.org/cgi/content/abstract/303/7/631
NEJM 18 Feb 2010 Vol 362
590 Some people like to see evidence from randomised controlled trials with hard end-points before a computer prediction that a certain intervention will reduce new cases of CHD in America by up to 120,000 annually, stroke by up to 66,000, and death by up to 92,000. The editorial on p. 650 suggests a saving in health costs of $10-24 billion. Aha, we save health costs by keeping older people alive longer, do we? Apart from that basic point, there is also the problem that the evidence for salt reduction is - as far as I can tell - nowhere near as strong as the computer model in this economic simulation suggests. The evidence we have is about a surrogate marker - blood pressure - which can be reduced slightly by the sort of salt reductions proposed here and already in force in the UK for prepared foods. On the balance of probabilities, I'm happy to support salt reduction, as I am carbon emission reduction; but that doesn't mean swallowing every extrapolation that zealots come up with. A paper like this doesn't really belong in the world's leading medical journal.
http://content.nejm.org/cgi/content/abstract/362/7/590
Ann Intern Med 16 Feb 2010 Vol 152
211 The Women's Health Initiative trial was an RCT of hormone replacement therapy which brought about a volte-face in clinical practice but which is described as "far from impeccable" in a letter in this week's BMJ (p.382). Peccability is openly confessed in this Lenten analysis of the effect of continuous combined HRT on coronary heart disease. They more or less admit to residual confounding and small subgroup sizes. The bottom line message is that continuous HRT may confer added risk of CHD in the first years, then decreased risk after 6 years. Which is not quite what we were all initially led to believe.
http://www.annals.org/content/152/4/211.abstract
218 Initiated permanent anticoagulation for severe recurrent superficial thrombophlebitis with the reluctant concurrence of the local haematologist. Such events are benign and self-limiting and do not herald serious thromboembolism, but this French study casts doubts on that. In fact 25% of subjects with superficial phlebitis of 5cm or more had or went on to develop deep vein thrombosis in this series of 844 consecutive cases in a specialist referral centre. We need some primary care studies, quite urgently.
http://www.annals.org/content/152/4/218.abstract
Lancet 27 Feb 2010 Vol 375
727 Not long ago, someone had a myocardial infarction on a transatlantic flight. So what does a professor of surgery do under these circumstances? Possibly take an aspirin and pray a good deal. He should have squeezed his arm repeatedly for periods of five minutes or so at a pressure above systolic. Believe it or not, this simple manoeuvre can reduce the area of myocardial damage, as proved in this Danish trial where patients with presumptive MI were randomised to have the squeezing done (or not done) by a sphygmomanometer in the ambulance conveying them to hospital. This is known as ischaemic preconditioning, though in such circumstances it should perhaps be known as simultaneous ischaemic conditioning. There were no hard end-points in this trial but a convincing reduction in damage on myocardial perfusion imaging at 30 days. More trials are needed, but meantime there seems no possible reason not to give it a try.
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(09)62001-8/abstract
752 This is a rather rambling 10-page review of dilated cardiomyopathy. The Panel of Mechanisms covers just about everything except interference by aliens, and there's a panel of gene loci too, but no panel of relative frequencies and prognoses for each aetiology. There is no mention of spontaneous recovery, which can't be rare if it has been seen twice.
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(09)62023-7/abstract
763 Say you had stable coronary artery disease: would you want an angiogram? And if the cardiologist saw a stenosis, would you want a stent put in? A year or two ago, these questions would have seemed like no-brainers, but then along came COURAGE and BARI-2D showing that medical treatment is as good as percutaneous intervention. Do you truly and deeply believe this, though? See how you feel when you read this review by two Swiss and an American cardiologist. It presents enough evidence to allow a tailored approach, and says that it "proposes a treatment algorithm that is applicable to daily clinical practice." The word "algorithm" is to be avoided, but people who use it generally refer to a flow chart, but there isn't one. http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(10)60168-7/abstract
BMJ 27 Feb 2010 Vol 340
459 A useful systematic review compares the results of carotid endarterectomy vs. carotid stenting in 11 randomised trials. On the face of it, endarterectomy wins, because the risk of periprocedural stroke is less; in the longer term there is little difference. Techniques and experience increase all the time - it may happen that the guy who puts in stents near you does that better than the guy who scrapes arteries. So more studies are justified and the matter is not quite settled yet.
http://www.bmj.com/cgi/content/full/340/feb12_1/c467
JAMA 17 Feb 2010 Vol 303
631 The Women's Genome Health Study is a prospective cohort of 19,313 women followed up for a median of 12.3 years, during which they experienced 777 cardiovascular events. In these women, 101 single nucleotide polymorphisms were added with one or two other genomic factors to create a genetic risk score. Surely this would usher in a new era of refined cardiovascular risk prediction? Well, actually it showed no significant association with the incidence of total cardiovascular disease: a simple family history alone was more predictive. On the other hand, there is so much anonymized data about the participants that you could probably find out the full disease status of any individual if you could identify their genome from some other source. This is discussed in a fascinating commentary on p.659. Genomic studies seem almost disconcertingly useless at the population level, but if you know 35,000 gene variants in a single individual, you can measure their left ventricular mass more accurately than if you had an echocardiogram.
http://jama.ama-assn.org/cgi/content/abstract/303/7/631
NEJM 18 Feb 2010 Vol 362
590 Some people like to see evidence from randomised controlled trials with hard end-points before a computer prediction that a certain intervention will reduce new cases of CHD in America by up to 120,000 annually, stroke by up to 66,000, and death by up to 92,000. The editorial on p. 650 suggests a saving in health costs of $10-24 billion. Aha, we save health costs by keeping older people alive longer, do we? Apart from that basic point, there is also the problem that the evidence for salt reduction is - as far as I can tell - nowhere near as strong as the computer model in this economic simulation suggests. The evidence we have is about a surrogate marker - blood pressure - which can be reduced slightly by the sort of salt reductions proposed here and already in force in the UK for prepared foods. On the balance of probabilities, I'm happy to support salt reduction, as I am carbon emission reduction; but that doesn't mean swallowing every extrapolation that zealots come up with. A paper like this doesn't really belong in the world's leading medical journal.
http://content.nejm.org/cgi/content/abstract/362/7/590
Ann Intern Med 16 Feb 2010 Vol 152
211 The Women's Health Initiative trial was an RCT of hormone replacement therapy which brought about a volte-face in clinical practice but which is described as "far from impeccable" in a letter in this week's BMJ (p.382). Peccability is openly confessed in this Lenten analysis of the effect of continuous combined HRT on coronary heart disease. They more or less admit to residual confounding and small subgroup sizes. The bottom line message is that continuous HRT may confer added risk of CHD in the first years, then decreased risk after 6 years. Which is not quite what we were all initially led to believe.
http://www.annals.org/content/152/4/211.abstract
218 Initiated permanent anticoagulation for severe recurrent superficial thrombophlebitis with the reluctant concurrence of the local haematologist. Such events are benign and self-limiting and do not herald serious thromboembolism, but this French study casts doubts on that. In fact 25% of subjects with superficial phlebitis of 5cm or more had or went on to develop deep vein thrombosis in this series of 844 consecutive cases in a specialist referral centre. We need some primary care studies, quite urgently.
http://www.annals.org/content/152/4/218.abstract
Tuesday, 23 February 2010
CARDIOVASCULAR HIGHLIGHTS
Spotlight on Vascular:
http://www.library.nhs.uk/vascular/
For the full list of additions to this collection, download the full Vascular e-bulletin here.
News in spotlight
New NICE care guideline published: Venous thromboembolism – reducing the risk
NICE is to develop a clinical guideline on Peripheral Arterial Disease. Access stakeholder guidelines from www.library.nhs.uk/vascular/ .
Hot off the press: 04/02/10 - Risk of Deep Vein Thrombosis Following a Single Negative Whole-Leg Compression Ultrasound
Hot off the press: 10/12/09 - Dabigatran versus Warfarin in the Treatment of Acute Venous Thromboembolism
Hot off the press: 27/11/09 - Aspirin for primary prevention of cardiovascular events in people with diabetes
Articles in spotlight
Endovascular aortic aneurysm repair (EVAR) has significantly lower perioperative mortality in comparison to open repair: a systematic review (DARE)
http://www.library.nhs.uk/VASCULAR/ViewResource.aspx?resID=331814
Physical activity in patients with deep venous thrombosis: a systematic review DARE
http://www.library.nhs.uk/VASCULAR/ViewResource.aspx?resID=331795
Prevention of venous thromboembolism in neurosurgery: a metaanalysis DARE
http://www.library.nhs.uk/VASCULAR/ViewResource.aspx?resID=334120
Events in spotlight
2nd International Conference on Early Disease Detection and Prevention (EDDP) 2010
25 Feb 2010 09:00 - 28 Feb 2010 17:00
SVT Advanced Study Day: Innovations and Applications of Portable Vascular Ultrasound 2010
26 Feb 2010 09:00 – 17:00
Vascular Disease Awareness Week 2010
08 Mar 2010 00:00 - 12 Mar 2010 23:45
The Vascular Society Spring Meeting 2010
11 Mar 2010 10:00 - 17:30
Live from the website: view events, breaking news, latest content
Recent additions
Events
News
Spotlight on Cardiovascular:
http://www.library.nhs.uk/cardiovascular/
For the full list of additions to this collection, download the full Cardiovascular e-bulletin here.
News in spotlight
02/01/10 - Catheter ablation of stable ventricular tachycardia before defibrillator implantation in patients with coronary heart disease (VTACH): a multicentre randomised controlled trial
http://www.library.nhs.uk/cardiovascular/viewResource.aspx?resid=334301
Hot off the press: 21/01/10 - Projected Effect of Dietary Salt Reductions on Future Cardiovascular Disease
Hot off the press: 27/01/10 - Comparison of Antiarrhythmic Drug Therapy and Radiofrequency Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation (RCT)
Hot off the press: 28/01/10 - Non-invasive cardiac stress testing before elective major non-cardiac surgery: population based cohort study
Hot off the press: 15/01/10 - Radiation exposure and circulatory disease risk: Hiroshima and Nagasaki atomic bomb survivor data, 1950-2003
Hot off the press: 15/01/10 - Use of angiotensin receptor blockers and risk of dementia in a predominantly male population
Articles in spotlight
Home-based versus centre-based cardiac rehabilitation Cochrane
http://www.library.nhs.uk/cardiovascular/viewResource.aspx?resid=334131
Aprotinin and the risk of death and renal dysfunction in patients undergoing cardiac surgery: a meta-analysis of epidemiologic studies DARE
http://www.library.nhs.uk/cardiovascular/viewResource.aspx?resid=334152
Events in spotlight
A Practical Approach to Physical Activity and Exercise in the Management of Cardiovascular Disease 2010
19 Feb 2010 09:00 - 20 Feb 2010 17:00
2nd International Conference on Early Disease Detection and Prevention (EDDP) 2010
25 Feb 2010 09:00 - 28 Feb 2010 17:00
SVT Advanced Study Day: Innovations and Applications of Portable Vascular Ultrasound
26 Feb 2010 09:00 - 17:15
Cardiology Review Course 2010
08 Mar 2010 09:00 - 12 Mar 2010 17:00
Live from the website: view events, breaking news, latest content
Recent additions
Events
News
Spotlight on Stroke:
http://www.library.nhs.uk/stroke/
For the full list of additions to this collection, download the full Stroke e-bulletin here.
News in spotlight
National Audit Office report Progress in improving stroke care published 3rd February:
http://www.library.nhs.uk/stroke/viewResource.aspx?resid=343170
The NICE stroke rehabilitation guideline is expected in March 2012:
04/01/10 - Stroke rehabilitation guideline announcement
Articles in spotlight
AHA scientific statement: Recommendations for imaging of acute ischemic stroke
http://www.library.nhs.uk/stroke/viewResource.aspx?resid=343354
Movement-dependent stroke recovery: a systematic review and meta-analysis of TMS and fMRI evidence
http://www.library.nhs.uk/stroke/viewResource.aspx?resid=331748 DARE
Multidisciplinary care planning in the primary care management of completed stroke: a systematic review
http://www.library.nhs.uk/stroke/viewResource.aspx?resid=331776 DARE
Caring for people after they have had a stroke
http://www.library.nhs.uk/stroke/viewResource.aspx?resid=123327 Care Quality Commission
Events in spotlight
2nd International Conference on Early Disease Detection and Prevention (EDDP) 2010
25 Feb 2010 09:00 - 28 Feb 2010 17:00
The 3rd International Conference on Hypertension, Lipids, Diabetes & Stroke Prevention 2010
04 Mar 2010 09:00 – 17:30
Live from the website: view events, breaking news, latest content
Recent additions
Events
News
We welcome feedback on our collections.
Please contact us at http://www.library.nhs.uk/Cardiovascular/ContactUs.aspx
http://www.library.nhs.uk/vascular/
For the full list of additions to this collection, download the full Vascular e-bulletin here.
News in spotlight
New NICE care guideline published: Venous thromboembolism – reducing the risk
NICE is to develop a clinical guideline on Peripheral Arterial Disease. Access stakeholder guidelines from www.library.nhs.uk/vascular/ .
Hot off the press: 04/02/10 - Risk of Deep Vein Thrombosis Following a Single Negative Whole-Leg Compression Ultrasound
Hot off the press: 10/12/09 - Dabigatran versus Warfarin in the Treatment of Acute Venous Thromboembolism
Hot off the press: 27/11/09 - Aspirin for primary prevention of cardiovascular events in people with diabetes
Articles in spotlight
Endovascular aortic aneurysm repair (EVAR) has significantly lower perioperative mortality in comparison to open repair: a systematic review (DARE)
http://www.library.nhs.uk/VASCULAR/ViewResource.aspx?resID=331814
Physical activity in patients with deep venous thrombosis: a systematic review DARE
http://www.library.nhs.uk/VASCULAR/ViewResource.aspx?resID=331795
Prevention of venous thromboembolism in neurosurgery: a metaanalysis DARE
http://www.library.nhs.uk/VASCULAR/ViewResource.aspx?resID=334120
Events in spotlight
2nd International Conference on Early Disease Detection and Prevention (EDDP) 2010
25 Feb 2010 09:00 - 28 Feb 2010 17:00
SVT Advanced Study Day: Innovations and Applications of Portable Vascular Ultrasound 2010
26 Feb 2010 09:00 – 17:00
Vascular Disease Awareness Week 2010
08 Mar 2010 00:00 - 12 Mar 2010 23:45
The Vascular Society Spring Meeting 2010
11 Mar 2010 10:00 - 17:30
Live from the website: view events, breaking news, latest content
Recent additions
Events
News
Spotlight on Cardiovascular:
http://www.library.nhs.uk/cardiovascular/
For the full list of additions to this collection, download the full Cardiovascular e-bulletin here.
News in spotlight
02/01/10 - Catheter ablation of stable ventricular tachycardia before defibrillator implantation in patients with coronary heart disease (VTACH): a multicentre randomised controlled trial
http://www.library.nhs.uk/cardiovascular/viewResource.aspx?resid=334301
Hot off the press: 21/01/10 - Projected Effect of Dietary Salt Reductions on Future Cardiovascular Disease
Hot off the press: 27/01/10 - Comparison of Antiarrhythmic Drug Therapy and Radiofrequency Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation (RCT)
Hot off the press: 28/01/10 - Non-invasive cardiac stress testing before elective major non-cardiac surgery: population based cohort study
Hot off the press: 15/01/10 - Radiation exposure and circulatory disease risk: Hiroshima and Nagasaki atomic bomb survivor data, 1950-2003
Hot off the press: 15/01/10 - Use of angiotensin receptor blockers and risk of dementia in a predominantly male population
Articles in spotlight
Home-based versus centre-based cardiac rehabilitation Cochrane
http://www.library.nhs.uk/cardiovascular/viewResource.aspx?resid=334131
Aprotinin and the risk of death and renal dysfunction in patients undergoing cardiac surgery: a meta-analysis of epidemiologic studies DARE
http://www.library.nhs.uk/cardiovascular/viewResource.aspx?resid=334152
Events in spotlight
A Practical Approach to Physical Activity and Exercise in the Management of Cardiovascular Disease 2010
19 Feb 2010 09:00 - 20 Feb 2010 17:00
2nd International Conference on Early Disease Detection and Prevention (EDDP) 2010
25 Feb 2010 09:00 - 28 Feb 2010 17:00
SVT Advanced Study Day: Innovations and Applications of Portable Vascular Ultrasound
26 Feb 2010 09:00 - 17:15
Cardiology Review Course 2010
08 Mar 2010 09:00 - 12 Mar 2010 17:00
Live from the website: view events, breaking news, latest content
Recent additions
Events
News
Spotlight on Stroke:
http://www.library.nhs.uk/stroke/
For the full list of additions to this collection, download the full Stroke e-bulletin here.
News in spotlight
National Audit Office report Progress in improving stroke care published 3rd February:
http://www.library.nhs.uk/stroke/viewResource.aspx?resid=343170
The NICE stroke rehabilitation guideline is expected in March 2012:
04/01/10 - Stroke rehabilitation guideline announcement
Articles in spotlight
AHA scientific statement: Recommendations for imaging of acute ischemic stroke
http://www.library.nhs.uk/stroke/viewResource.aspx?resid=343354
Movement-dependent stroke recovery: a systematic review and meta-analysis of TMS and fMRI evidence
http://www.library.nhs.uk/stroke/viewResource.aspx?resid=331748 DARE
Multidisciplinary care planning in the primary care management of completed stroke: a systematic review
http://www.library.nhs.uk/stroke/viewResource.aspx?resid=331776 DARE
Caring for people after they have had a stroke
http://www.library.nhs.uk/stroke/viewResource.aspx?resid=123327 Care Quality Commission
Events in spotlight
2nd International Conference on Early Disease Detection and Prevention (EDDP) 2010
25 Feb 2010 09:00 - 28 Feb 2010 17:00
The 3rd International Conference on Hypertension, Lipids, Diabetes & Stroke Prevention 2010
04 Mar 2010 09:00 – 17:30
Live from the website: view events, breaking news, latest content
Recent additions
Events
News
We welcome feedback on our collections.
Please contact us at http://www.library.nhs.uk/Cardiovascular/ContactUs.aspx
Thursday, 28 January 2010
EVIDENCE UPDATES
22 February
Chest pain (NHS Evidence - cardiovascular)
www.library.nhs.uk/cardiovascular
The 2010 Annual Evidence Update on Chest Pain seeks to identify key new systematic reviews and related documents published since the 2009 update and so identify the latest high quality evidence on this topic. The evidence will be accompanied by summaries from experts providing a commentary on the new evidence and whether this challenges current guidance/practice or identifies uncertainties in our knowledge on this topic.
Chest pain (NHS Evidence - cardiovascular)
www.library.nhs.uk/cardiovascular
The 2010 Annual Evidence Update on Chest Pain seeks to identify key new systematic reviews and related documents published since the 2009 update and so identify the latest high quality evidence on this topic. The evidence will be accompanied by summaries from experts providing a commentary on the new evidence and whether this challenges current guidance/practice or identifies uncertainties in our knowledge on this topic.
Thursday, 10 December 2009
ETHNICITY and CARDIOVASCULAR ISSUES
Cardiovascular Diseases:
Ethnic and sex differences in circulating endotoxin levels: a novel marker of atherosclerotic and cardiovascular risk in a British multi-ethnic population
Ethnic differences in pro-inflammatory markers maybe related to ethnic differences in atherosclerotic and cardiovascular (CVD) and coronary (CHD) heart disease; this study investigates ethnic differences in circulating plasma endotoxin levels.
Race and ethnicity in trials of antihypertensive therapy to prevent cardiovascular outcomes: a systematic review
Racial and ethnic differences in the efficacy of hypertensive therapies for the prevention of cardiovascular outcomes are assessed.
Ethnic and sex differences in circulating endotoxin levels: a novel marker of atherosclerotic and cardiovascular risk in a British multi-ethnic population
Ethnic differences in pro-inflammatory markers maybe related to ethnic differences in atherosclerotic and cardiovascular (CVD) and coronary (CHD) heart disease; this study investigates ethnic differences in circulating plasma endotoxin levels.
Race and ethnicity in trials of antihypertensive therapy to prevent cardiovascular outcomes: a systematic review
Racial and ethnic differences in the efficacy of hypertensive therapies for the prevention of cardiovascular outcomes are assessed.
Wednesday, 9 December 2009
Eyes on Evidence
NHS Evidence - cardiovascular aims to provide high quality, evidence-based information on all aspects of cardiovascular diseases. This site is aimed at health professionals with an interest in cardiovascular diseases.
NHS Evidence - Cardiovascular - News
News alerts from the NHS Evidence Cardiovascular Specialist Collection
Hot off the press: 04/12/09 - Salt intake, stroke, and cardiovascular disease
Hot off the press: 03/12/09 - Advanced Heart Failure Treated with Continuous-Flow Left Ventricular Assist Device
02/12/09 - National Heart Forum Bulletin
NHS Evidence - cardiovascular presents the 2009 Annual Evidence Update on Heart Failure.Further information on previous evidence updates
View our Events Calendar (RSS Feed) to find out about up-and-coming conferences and meetings in cardiovascular topic areas.
Key Organisations in the field of Cardiovascular Diseases. Information about cardiac networks is available via visiting Man agement issues > Networks topic within the left hand menu.
The Database of Uncertainties about the Effects of Treatments can help prioritise new research. If you've a CVD treatment uncertainty please complete our DUETs feedback form.
NHS Evidence - Cardiovascular - News
News alerts from the NHS Evidence Cardiovascular Specialist Collection
Hot off the press: 04/12/09 - Salt intake, stroke, and cardiovascular disease
Hot off the press: 03/12/09 - Advanced Heart Failure Treated with Continuous-Flow Left Ventricular Assist Device
02/12/09 - National Heart Forum Bulletin
NHS Evidence - cardiovascular presents the 2009 Annual Evidence Update on Heart Failure.Further information on previous evidence updates
View our Events Calendar (RSS Feed) to find out about up-and-coming conferences and meetings in cardiovascular topic areas.
Key Organisations in the field of Cardiovascular Diseases. Information about cardiac networks is available via visiting Man agement issues > Networks topic within the left hand menu.
The Database of Uncertainties about the Effects of Treatments can help prioritise new research. If you've a CVD treatment uncertainty please complete our DUETs feedback form.
Thursday, 29 October 2009
ARTICLES
New comments from Journal Watch by Richard Lehman
JAMA 21 Oct 2009 Vol 302
1651 This morning I bought a 2kg turbot and I am in a good mood. Turbot is a fish containing huge amounts of omega-3 fatty acids and is the sort that Bertie Wooster recommended to Jeeves for the good of his brain, since it has long been recognised that these fishy acids are concentrated in cerebral synapses. The study here looks at whether adding omega 3 supplements improves the action of setraline in depressed patients with coronary heart disease. The preparation used seemed to have no effect over 10 weeks. Come over to our place for a dish of turbot and a glass or two of Mersault and I bet you’ll notice an immediate difference.
http://jama.ama-assn.org/cgi/content/abstract/302/15/1651
1658 The history of heart failure research over the last 30 years is largely the history of blocking various stages of the renin-angiotensin-aldosterone pathway in patients with a reduced systolic ejection fraction. We have now reached the stage of being able to block everything in the pathway, from renin at the start to aldosterone at the finish. Historically it went the other way, because I was using spironolactone (with furosemide) for most ward patients with heart failure as a houseman in the mid 1970s, whereas ACE inhibitors and angiotensin receptor blockers came much later, and direct renin antagonists last of all. Despite an enormous number of randomised controlled trials of these agents in systolic heart failure, the evidence base for their rational deployment remains a mess. We do know from several trials that aldosterone blockade with spironolactone or eplerenone can improve symptoms and outcomes in patients with systolic HF who are already taking blockers of the earlier stages in the pathway. This study looks at whether they are being used appropriately in a group of American hospitals taking part in a HF Quality Improvement programme. You’d think that such participation would have an enormous Hawthorne effect, raising standards of treatment without further intervention, but not so: two thirds of HF patients admitted to these hospitals leave without an aldosterone antagonist. Think about this when you next see someone with worsening heart failure. And above all, think about why their HF has got worse.
http://jama.ama-assn.org/cgi/content/abstract/302/15/1658
1666 Being a twin in Sweden means that your lifetime medical history will be closely watched, even if you and your sibling popped out as long ago as 1914. There were in fact 31 936 twins born in Sweden between 1914 and 1944, should this question ever arise in a pub quiz. Following their fate allows us all sorts of insights into common associations – such as the unexpected one between cardiovascular diseases and hip fracture. Just having ischaemic heart disease doubles your risk of a hip fracture: having heart failure doubles it again, and having a stroke brings an even higher risk. Various explanations come to mind, but the question which intrigues me most is whether these Nordic twins may suffer both cardiovascular disease and fractures because they are short of vitamin D.
http://jama.ama-assn.org/cgi/content/abstract/302/15/1666
1698 One subject I did make an attempt to look at in greater depth earlier this year was the issue of cardiovascular outcomes in type 2 diabetes trials. Worms crawled out of every can, and they continue to emerge, as in this brief piece about variations in event rates. These vary fourfold between ostensibly comparable diabetic populations recruited to key studies. Why? It’s your turn to chase that worm; I’ve done my bit, and I’m tired.
http://jama.ama-assn.org/cgi/content/abstract/302/15/1685
JAMA 21 Oct 2009 Vol 302
1651 This morning I bought a 2kg turbot and I am in a good mood. Turbot is a fish containing huge amounts of omega-3 fatty acids and is the sort that Bertie Wooster recommended to Jeeves for the good of his brain, since it has long been recognised that these fishy acids are concentrated in cerebral synapses. The study here looks at whether adding omega 3 supplements improves the action of setraline in depressed patients with coronary heart disease. The preparation used seemed to have no effect over 10 weeks. Come over to our place for a dish of turbot and a glass or two of Mersault and I bet you’ll notice an immediate difference.
http://jama.ama-assn.org/cgi/content/abstract/302/15/1651
1658 The history of heart failure research over the last 30 years is largely the history of blocking various stages of the renin-angiotensin-aldosterone pathway in patients with a reduced systolic ejection fraction. We have now reached the stage of being able to block everything in the pathway, from renin at the start to aldosterone at the finish. Historically it went the other way, because I was using spironolactone (with furosemide) for most ward patients with heart failure as a houseman in the mid 1970s, whereas ACE inhibitors and angiotensin receptor blockers came much later, and direct renin antagonists last of all. Despite an enormous number of randomised controlled trials of these agents in systolic heart failure, the evidence base for their rational deployment remains a mess. We do know from several trials that aldosterone blockade with spironolactone or eplerenone can improve symptoms and outcomes in patients with systolic HF who are already taking blockers of the earlier stages in the pathway. This study looks at whether they are being used appropriately in a group of American hospitals taking part in a HF Quality Improvement programme. You’d think that such participation would have an enormous Hawthorne effect, raising standards of treatment without further intervention, but not so: two thirds of HF patients admitted to these hospitals leave without an aldosterone antagonist. Think about this when you next see someone with worsening heart failure. And above all, think about why their HF has got worse.
http://jama.ama-assn.org/cgi/content/abstract/302/15/1658
1666 Being a twin in Sweden means that your lifetime medical history will be closely watched, even if you and your sibling popped out as long ago as 1914. There were in fact 31 936 twins born in Sweden between 1914 and 1944, should this question ever arise in a pub quiz. Following their fate allows us all sorts of insights into common associations – such as the unexpected one between cardiovascular diseases and hip fracture. Just having ischaemic heart disease doubles your risk of a hip fracture: having heart failure doubles it again, and having a stroke brings an even higher risk. Various explanations come to mind, but the question which intrigues me most is whether these Nordic twins may suffer both cardiovascular disease and fractures because they are short of vitamin D.
http://jama.ama-assn.org/cgi/content/abstract/302/15/1666
1698 One subject I did make an attempt to look at in greater depth earlier this year was the issue of cardiovascular outcomes in type 2 diabetes trials. Worms crawled out of every can, and they continue to emerge, as in this brief piece about variations in event rates. These vary fourfold between ostensibly comparable diabetic populations recruited to key studies. Why? It’s your turn to chase that worm; I’ve done my bit, and I’m tired.
http://jama.ama-assn.org/cgi/content/abstract/302/15/1685
Friday, 29 May 2009
NHS EVIDENCE - cardiovascular
Annual Evidence Update on Atrial Fibrillation (NHS Evidence - cardiovascular)
www.library.nhs.uk/cardiovascular
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and if left untreated is a significant risk factor for stroke and other morbidities. NICE published a guideline on management of AF in June 2006. The NHS Evidence - cardiovascular team has systematically identified high quality evidence that has appeared since then, and will present this with summaries written by leading experts in the field.
www.library.nhs.uk/cardiovascular
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and if left untreated is a significant risk factor for stroke and other morbidities. NICE published a guideline on management of AF in June 2006. The NHS Evidence - cardiovascular team has systematically identified high quality evidence that has appeared since then, and will present this with summaries written by leading experts in the field.
Monday, 1 December 2008
Vascular Specialist Library
The National Library for Health launched the Vascular Specialist library at the Vascular Society AGM in Bournemouth on the 12th November 08. This new online resource builds on previous work on Cardiovascular Diseases and Stroke. The Vascular Library provides information on the prevention, diagnosis and management of diseases of the arteries, veins and lymphatic's. Updating the reader on high quality evidence in the prevention, diagnosis and treatment of vascular disease. The library aims to improve patient care through keeping the reader at the cutting edge of the rapidly evolving technologies used in the modern treatment of vascular conditions with strong links to the specialist societies and key organizations in the field of vascular disease.
The Vascular Library aims to be a resource for all health professionals with an interest in vascular disease, from surgeons and physicians to radiologists, nurses, podiatrists, sonographers and technicians. It is also accessible to the general public, and we are working with NHS Choices to help develop high quality patient information.
The core content of the Vascular Library includes systematic reviews, NICE guidelines, health policy initiatives and evaluated patient information. Data from national standards, statistics and audit are also featured. The library will expand and become richer with time, guided by an excellent, multidisciplinary Steering Group co-chaired by Mr. Rajiv Vohra, consultant vascular surgeon at University Hospital Birmingham NHS Foundation Trust and Professor Tom Quinn, clinical lead for the Cardiovascular, Stroke and Vascular Libraries, supported by project manager April Coombe.
The Library team are keen to hear from colleagues interested in becoming topic advisers or providing an editorial on an area of special interest.
The Vascular Library aims to be a resource for all health professionals with an interest in vascular disease, from surgeons and physicians to radiologists, nurses, podiatrists, sonographers and technicians. It is also accessible to the general public, and we are working with NHS Choices to help develop high quality patient information.
The core content of the Vascular Library includes systematic reviews, NICE guidelines, health policy initiatives and evaluated patient information. Data from national standards, statistics and audit are also featured. The library will expand and become richer with time, guided by an excellent, multidisciplinary Steering Group co-chaired by Mr. Rajiv Vohra, consultant vascular surgeon at University Hospital Birmingham NHS Foundation Trust and Professor Tom Quinn, clinical lead for the Cardiovascular, Stroke and Vascular Libraries, supported by project manager April Coombe.
The Library team are keen to hear from colleagues interested in becoming topic advisers or providing an editorial on an area of special interest.
Wednesday, 21 May 2008
Cardiovascular Newsletter
Dear Colleague
The March edition of the Cardiovascular Diseases Specialist Library
(CVDSL) bulletin can now be found at the link below. This bulletin is designed to update you on the latest additions to the CVDSL.
http://www.library.nhs.uk/cardiovascular/Page.aspx?prv=y&pagename=BULL30
The main CVDSL website is available at:
http://www.library.nhs.uk/cardiovascular/
<http://www.library.nhs.uk/cardiovascular/>
We would like your feedback. If you have any comments/suggestions please contact me (details below).
If you would like link to the bulletin from your websites, intranets or newsletters, the CVDSL team are happy for you to do so.
Kind Regards
April
April Coombe
CVDSL Project Manager
Workforce Deanery
NHS West Midlands
St Chad's Court
213 Hagley Road
Edgbaston
Birmingham
B16 9RG
Email: april.coombe@westmidlands.nhs.uk
The March edition of the Cardiovascular Diseases Specialist Library
(CVDSL) bulletin can now be found at the link below. This bulletin is designed to update you on the latest additions to the CVDSL.
http://www.library.nhs.uk/cardiovascular/Page.aspx?prv=y&pagename=BULL30
The main CVDSL website is available at:
http://www.library.nhs.uk/cardiovascular/
<http://www.library.nhs.uk/cardiovascular/>
We would like your feedback. If you have any comments/suggestions please contact me (details below).
If you would like link to the bulletin from your websites, intranets or newsletters, the CVDSL team are happy for you to do so.
Kind Regards
April
April Coombe
CVDSL Project Manager
Workforce Deanery
NHS West Midlands
St Chad's Court
213 Hagley Road
Edgbaston
Birmingham
B16 9RG
Email: april.coombe@westmidlands.nhs.uk
Tuesday, 15 April 2008
Journal buzz
NEW CARDIOLOGY JOURNAL
Springer and International Society for Cardiovascular Translational Research (ISCTR) have founded the Journal of Cardiovascular Translational Research (JCTR) a quarterly biomedical publication. The JCTR will publish original papers in cellular therapy, genomics, personalised medicine and devices for the potential treatment of advanced cardiovascular disease.The aim of the journal is to provide outstanding peer-reviewed articles with implications for the current and future practice of clinical cardiovascular medicine. It will provide content in which translational research involving multiple disciplines such as genetics, proteomics, epidemiology and preclinical and clinical research is used interchangeably within a study to advance the understanding of disease or response to treatment.
JOURNAL PARTNERSHIP
Oxford Journals and the European Society of Cardiology (ESC) have announced a publishing partnership for the European Journal of Echocardiography, starting this year. This will be the fourth of the ESC's titles to join Oxford Journals, following European heart Journal in 2005, Europace in 2006 and Cardiovascular Research, which is also being launched by Oxford Journals for 2008. The European Journal of Echocardiography is the journal of the European Association of Echocardiography, a registered branch of the European Society of Cardiology. its articles focus on the ultrasonic examination of the cardiovascular system, including ischaemic heart disease, valve disease, cardiomyopathy, congenital heart disease, and vascular disease.
Springer and International Society for Cardiovascular Translational Research (ISCTR) have founded the Journal of Cardiovascular Translational Research (JCTR) a quarterly biomedical publication. The JCTR will publish original papers in cellular therapy, genomics, personalised medicine and devices for the potential treatment of advanced cardiovascular disease.The aim of the journal is to provide outstanding peer-reviewed articles with implications for the current and future practice of clinical cardiovascular medicine. It will provide content in which translational research involving multiple disciplines such as genetics, proteomics, epidemiology and preclinical and clinical research is used interchangeably within a study to advance the understanding of disease or response to treatment.
JOURNAL PARTNERSHIP
Oxford Journals and the European Society of Cardiology (ESC) have announced a publishing partnership for the European Journal of Echocardiography, starting this year. This will be the fourth of the ESC's titles to join Oxford Journals, following European heart Journal in 2005, Europace in 2006 and Cardiovascular Research, which is also being launched by Oxford Journals for 2008. The European Journal of Echocardiography is the journal of the European Association of Echocardiography, a registered branch of the European Society of Cardiology. its articles focus on the ultrasonic examination of the cardiovascular system, including ischaemic heart disease, valve disease, cardiomyopathy, congenital heart disease, and vascular disease.
Monday, 31 March 2008
Cardiovascular newsletter
Cardiovascular Diseases Specialist Library Bulletin: Issue No 29 - March 08
www.library.nhs.uk/cardiovascular/
This Bulletin is designed to update you on the latest additions to the CVDSL.
Recent Publications:
20/02/2008 – Commissioning Guides, Cardiac Rehabilitation Services NICE
20/03/2008 –Commissioning Guides, Commissioning Guides: Heart failure service for the management of chronic heart failure NICE
This months additions to the Centre for Reviews and Dissemination’s Database of Abstracts of Reviews of Effects (DARE) [1]
Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomised clinical trials Lago R M, Singh P P Nesto R W; Lancet, 2007
Effect of cocoa and tea intake on blood pressure Taubert D, Roesen R, Schomig E, Archives of Internal Medicine, 2007
The impact of continuous positive airway pressure on blood pressure in patients with obstructive sleep apnea syndrome: evidence from a meta-analysis of placebo-controlled randomized trials Haentjens P, Van Meerhaeghe A, Moscariello A, De Weerdt S, Poppe K, Dupont A, Velkeniers B; Archives of Internal Medicine, 2007.
Effects of exercise training on cardiac performance, exercise capacity and quality of life in patients with heart failure: a meta-analysis van Tol B A, Huijsmans R J, Kroon D W, Schothorst M, Kwakkel G; European Journal of Heart Failure Abstract, 2007.
Vasodilator therapy in patients with aortic insufficiency: a systematic review Mahajerin A, Gurm H S, Tsai T T, Chan P S, Nallamothu B K; American Heart Journal, 2007.
Accuracy of B-type natriuretic peptide levels in the diagnosis of left ventricular dysfunction and heart failure: a systematic review Latour-Perez J, Coves-Orts F J, Abad-Terrado C, Abraira V, Zamora J; European Journal of Heart Failure, 2007.
Detection of heart transplant rejection in adults by echocardiographic diastolic indices: a systematic review of the literature Mena C, Wencker D, Krumholz H M, McNamara R L ;Journal of the American Society of Echocardiograp,2007.
Outcomes associated with drug-eluting and bare-metal stents: a collaborative network meta-analysis Stettler C, Wandel S, Allermann S, Kastrati A, Morice M C, Schomig A, Pfisterer M E, Stone G W, Leon M B, Suarez de Lezo J, Goy J J, Park S J, Sabate M, Suttorp M J, Kelbaek H, Spaulding C, Menichelli M, Vermeersch P, Dirksen M T, Cervinka P, Petronio A S, Nordmann A J, Diem P, Meier B, Zwahlen M, Reichenbach S, Trelle S, Windecker S, Juni P; Lancet, 2007.
Rescue angioplasty or repeat fibrinolysis after failed fibrinolytic therapy for ST-segment myocardial infarction: a meta-analysis of randomized trials Wijeysundera H C, Vijayaraghavan R, Nallamothu B K, Foody J M, Krumholz H M, Phillips C O, Kashani A, You J J, Tu J V, Ko D T; Journal of the American College of Cardiology, 2007.
Telemonitoring or structured telephone support programmes for patients with chronic heart failure: systematic review and meta-analysis Clark R A, Inglis S C, McAlister F A, Cleland J G, Stewart S; BMJ,2007.
This months additions to the Centre for Reviews and Dissemination’s Economic Evaluations Database(EED)
There were no new relevant Economic Evaluations added this month
Hot off the press:
Recently published articles from The Lancethttp://www.library.nhs.uk/cardiovascular, BMJ, NEJM and JAMA
For further information on appraising current awareness journal articles visit the literature appraisal guides section of the Cardiovascular Diseases Specialist Library.
27/03/08 - Coronary calcium as a predictor of coronary events in four racial or ethnic groups NEJM 2008;358:1336-1345
21/03/08 - Effects of statins in patients with chronic kidney disease: meta-analysis and meta-regression of randomised controlled BMJ 2008;336:645-651
20/03/08 - Duration of red-cell storage and complications after cardiac surgery
NEJM 2008;358:1229-1239
20/03/08 - Polymorphisms associated with cholesterol and risk of cardiovascular events NEJM 2008;358:1240-1249
18/03/08 - Use of bisphosphonates among women and risk of atrial fibrillation and flutter: population based case-control BMJ, doi:10.1136/bmj.39507.551644.BE (published 11 March 2008)
14/03/08 - Effect of immunisation against angiotensin II with CYT006-AngQb on ambulatory blood pressure: a double-blind, randomised, placebo-controlled phase IIa study The Lancet 2008; 371:821-827
12/03/08 - Minimally Interrupted Cardiac Resuscitation by Emergency Medical Services for Out-of-Hospital Cardiac Arrest JAMA. 2008;299(10):1158-1165.
07/03/08 - Degenerative aortic stenosis BMJ 2008;336:550-555
06/03/08 - Genetic determinants of response to warfarin during initial anticoagulation NEJM 2007;358:999-1008
05/03/08 - Health risks and benefits 3 years after stopping randomized treatment with estrogen and progestin JAMA 2008;299(9):1036-1045
27/02/08 - Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia JAMA 2008;299(8):914-924
Conferences and events for next three months
April 2008
May 2008
June 2008
News
26/03/08 – National Heart Forum Weekly News Briefing
19/03/08 - National Heart Forum Weekly News Briefing
12/03/08 - National Heart Forum Weekly News Briefing
05/03/08 - National Heart Forum Weekly News Briefing
New developments
Please support Arrhythmia Awareness Week 2008: 9th - 15th June
Launch of new national improvement programme
NHS Improvement brings together the practical service improvement experience of the Heart Improvement Programme, Cancer Services Collaborative ‘Improvement Partnership’; Diagnostics Service Improvement Programme and the Stroke Improvement Programme, into one newly formed team. The work of NHS Improvement will support delivery of the National Service Framework for CHD; National Stroke Strategy; Cancer Reform Strategy; and the 18 Week Programme.
Our clinical lead is:
PROFESSOR TOM QUINN FRCN FESC
Co-Director
Pre-hospital, Emergency and Cardiovascular Care
Applied Research Group (PHECC)
Faculty of Health and Life Sciences
Coventry University
Coventry CV1 5FB, UK
email t.quinn@coventry.ac.uk
--------------------------------------------------------------------------------
[1] All systematic reviews included in DARE have meet DARE’s strict quality criteria. Due to this quality procedure and the critical commentary on the quality of the review, there may be a time difference between when the systematic review has been published and when it appears in DARE.
www.library.nhs.uk/cardiovascular/
This Bulletin is designed to update you on the latest additions to the CVDSL.
Recent Publications:
20/02/2008 – Commissioning Guides, Cardiac Rehabilitation Services NICE
20/03/2008 –Commissioning Guides, Commissioning Guides: Heart failure service for the management of chronic heart failure NICE
This months additions to the Centre for Reviews and Dissemination’s Database of Abstracts of Reviews of Effects (DARE) [1]
Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomised clinical trials Lago R M, Singh P P Nesto R W; Lancet, 2007
Effect of cocoa and tea intake on blood pressure Taubert D, Roesen R, Schomig E, Archives of Internal Medicine, 2007
The impact of continuous positive airway pressure on blood pressure in patients with obstructive sleep apnea syndrome: evidence from a meta-analysis of placebo-controlled randomized trials Haentjens P, Van Meerhaeghe A, Moscariello A, De Weerdt S, Poppe K, Dupont A, Velkeniers B; Archives of Internal Medicine, 2007.
Effects of exercise training on cardiac performance, exercise capacity and quality of life in patients with heart failure: a meta-analysis van Tol B A, Huijsmans R J, Kroon D W, Schothorst M, Kwakkel G; European Journal of Heart Failure Abstract, 2007.
Vasodilator therapy in patients with aortic insufficiency: a systematic review Mahajerin A, Gurm H S, Tsai T T, Chan P S, Nallamothu B K; American Heart Journal, 2007.
Accuracy of B-type natriuretic peptide levels in the diagnosis of left ventricular dysfunction and heart failure: a systematic review Latour-Perez J, Coves-Orts F J, Abad-Terrado C, Abraira V, Zamora J; European Journal of Heart Failure, 2007.
Detection of heart transplant rejection in adults by echocardiographic diastolic indices: a systematic review of the literature Mena C, Wencker D, Krumholz H M, McNamara R L ;Journal of the American Society of Echocardiograp,2007.
Outcomes associated with drug-eluting and bare-metal stents: a collaborative network meta-analysis Stettler C, Wandel S, Allermann S, Kastrati A, Morice M C, Schomig A, Pfisterer M E, Stone G W, Leon M B, Suarez de Lezo J, Goy J J, Park S J, Sabate M, Suttorp M J, Kelbaek H, Spaulding C, Menichelli M, Vermeersch P, Dirksen M T, Cervinka P, Petronio A S, Nordmann A J, Diem P, Meier B, Zwahlen M, Reichenbach S, Trelle S, Windecker S, Juni P; Lancet, 2007.
Rescue angioplasty or repeat fibrinolysis after failed fibrinolytic therapy for ST-segment myocardial infarction: a meta-analysis of randomized trials Wijeysundera H C, Vijayaraghavan R, Nallamothu B K, Foody J M, Krumholz H M, Phillips C O, Kashani A, You J J, Tu J V, Ko D T; Journal of the American College of Cardiology, 2007.
Telemonitoring or structured telephone support programmes for patients with chronic heart failure: systematic review and meta-analysis Clark R A, Inglis S C, McAlister F A, Cleland J G, Stewart S; BMJ,2007.
This months additions to the Centre for Reviews and Dissemination’s Economic Evaluations Database(EED)
There were no new relevant Economic Evaluations added this month
Hot off the press:
Recently published articles from The Lancethttp://www.library.nhs.uk/cardiovascular, BMJ, NEJM and JAMA
For further information on appraising current awareness journal articles visit the literature appraisal guides section of the Cardiovascular Diseases Specialist Library.
27/03/08 - Coronary calcium as a predictor of coronary events in four racial or ethnic groups NEJM 2008;358:1336-1345
21/03/08 - Effects of statins in patients with chronic kidney disease: meta-analysis and meta-regression of randomised controlled BMJ 2008;336:645-651
20/03/08 - Duration of red-cell storage and complications after cardiac surgery
NEJM 2008;358:1229-1239
20/03/08 - Polymorphisms associated with cholesterol and risk of cardiovascular events NEJM 2008;358:1240-1249
18/03/08 - Use of bisphosphonates among women and risk of atrial fibrillation and flutter: population based case-control BMJ, doi:10.1136/bmj.39507.551644.BE (published 11 March 2008)
14/03/08 - Effect of immunisation against angiotensin II with CYT006-AngQb on ambulatory blood pressure: a double-blind, randomised, placebo-controlled phase IIa study The Lancet 2008; 371:821-827
12/03/08 - Minimally Interrupted Cardiac Resuscitation by Emergency Medical Services for Out-of-Hospital Cardiac Arrest JAMA. 2008;299(10):1158-1165.
07/03/08 - Degenerative aortic stenosis BMJ 2008;336:550-555
06/03/08 - Genetic determinants of response to warfarin during initial anticoagulation NEJM 2007;358:999-1008
05/03/08 - Health risks and benefits 3 years after stopping randomized treatment with estrogen and progestin JAMA 2008;299(9):1036-1045
27/02/08 - Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia JAMA 2008;299(8):914-924
Conferences and events for next three months
April 2008
May 2008
June 2008
News
26/03/08 – National Heart Forum Weekly News Briefing
19/03/08 - National Heart Forum Weekly News Briefing
12/03/08 - National Heart Forum Weekly News Briefing
05/03/08 - National Heart Forum Weekly News Briefing
New developments
Please support Arrhythmia Awareness Week 2008: 9th - 15th June
Launch of new national improvement programme
NHS Improvement brings together the practical service improvement experience of the Heart Improvement Programme, Cancer Services Collaborative ‘Improvement Partnership’; Diagnostics Service Improvement Programme and the Stroke Improvement Programme, into one newly formed team. The work of NHS Improvement will support delivery of the National Service Framework for CHD; National Stroke Strategy; Cancer Reform Strategy; and the 18 Week Programme.
Our clinical lead is:
PROFESSOR TOM QUINN FRCN FESC
Co-Director
Pre-hospital, Emergency and Cardiovascular Care
Applied Research Group (PHECC)
Faculty of Health and Life Sciences
Coventry University
Coventry CV1 5FB, UK
email t.quinn@coventry.ac.uk
--------------------------------------------------------------------------------
[1] All systematic reviews included in DARE have meet DARE’s strict quality criteria. Due to this quality procedure and the critical commentary on the quality of the review, there may be a time difference between when the systematic review has been published and when it appears in DARE.
Monday, 10 December 2007
Essex Cardiothoracic Centre at Basildon Hospital Information Spot
This is a new site set up so that you can share information through all the cardio departments at Basildon Hospital as well as other centres in UK and overseas.
It is hoped that you can download podcasts so you can see and hear specialists, set up RSS feeds so that the latest news on cardio and related subjects can be published, keep you up to date with conferences and publications and be aware of government initiatives.
Ideas can be shared on how to achieve the hospitals core targets, evidence best practice and keep yourself up to date. It is hoped that we can all add useful information on this space.
Your views comments and contributions are essential for the success of this site.
Here is a reminder back to July at the opening of the centre by Gordon Brown
http://www.youtube.com/watch?v=8_nFUxAhcJw
It is hoped that you can download podcasts so you can see and hear specialists, set up RSS feeds so that the latest news on cardio and related subjects can be published, keep you up to date with conferences and publications and be aware of government initiatives.
Ideas can be shared on how to achieve the hospitals core targets, evidence best practice and keep yourself up to date. It is hoped that we can all add useful information on this space.
Your views comments and contributions are essential for the success of this site.
Here is a reminder back to July at the opening of the centre by Gordon Brown
http://www.youtube.com/watch?v=8_nFUxAhcJw
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