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Cardiovascular disease

Systematic review: glucose control and cardiovascular disease in type 2 diabetes

Centre for Reviews and Dissemination


Systematic review: glucose control and cardiovascular disease in type 2 diabetes
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Author's objectives
To evaluate the benefits and harms of intensive versus conventional glucose control for adults with type 2 diabetes.
Author's conclusions
Intensive glucose control reduced the risk for some cardiovascular disease outcomes (such as non-fatal myocardial infarction), did not reduce the risk for cardiovascular death or all-cause mortality, and increased the risk for severe hypoglycaemia.
Bibliographic details
Kelly T N, Bazzano L A, Fonseca V A, Thethi T K, Reynolds K, He J. Systematic review: glucose control and cardiovascular disease in type 2 diabetes. Annals of Internal Medicine, 2009; 151(6): 394-403
Status
This record is a structured abstract written by CRD reviewers. The original has met a set of quality criteria.
CRD commentary
The review question was supported by clear inclusion criteria for participants, intervention, outcomes and study design. The search was limited to only one database. No language restrictions were applied, reducing the possibility of language bias in this database. Limited efforts to retrieve unpublished data were reported, which may have reduced the possibility of publication bias. Study selection and data extraction were performed in duplicate, reducing the risk of error and bias. It was not clear how many reviewers were involved in validity assessment.
Data were pooled in meta analyses and seemed to be appropriate as statistical and clinical heterogeneity were assessed and taken into consideration. Statistical heterogeneity remained present for some outcomes, suggesting other sources of variation. Reporting of intensive and comparator treatments were unclear for one study. Though language and publication bias cannot be ruled out this appeared to be a reasonably well-conducted review and the conclusions are likely to be reliable.
Publication Date: 30 Sep 2009
Publication Type: Structured Abstract
Publisher: Centre for Reviews and Dissemination
Source: Database of Abstracts of Reviews of Effects
Creator: Centre for Reviews and Dissemination
Topics
Outcomes
Circulatory diseases
Cardiovascular diseases
Endocrine disorders
Diabetes
The following specialist collections also reference this resource
Cardiovascular
Diabetes